USMLE Step 1 Renal Physiology 1 Review 58 14 The Glomerular Filtration Barrier

USMLE Step 1 Renal Physiology 1 Review 58 14 The Glomerular Filtration Barrier

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Play USMLE Audio MP3 58 14 The Glomerular Filtration Barrier Below

Begin 58 14 The Glomerular Filtration Barrier Transcription

The glomerular filtration barrier is composed of three layers. List them alphabetically. I’ll cue you. First, EL. Epithelial layer. Second, FCE. Fenestrated capillary endothelium. Third, FBM. Fused basement membrane.

Which layer is against the blood?

  • The fenestrated capillary endothelium.

And what kind of barrier is this?

  • The fenestrated capillary endothelium is a size barrier.

What is the diameter of the filtration pores in this layer?

  • The filtration pores are between 7.5 and 10 nanometers in diameter.

Which layer is in the middle?

  • The fused basement membrane.

And what does this layer contain? It starts with HS.

  • The fused basement membrane contains heparin sulfate.

And what kind of barrier is it?

  • A negative charge barrier.

And what is it repelling? The answer starts with an A.

  • The fused basement membrane repels albumin in the blood.

Which layer of the glomerular filtration barrier is on the nephron side?

  • The epithelial layer.

What process does the epithelial layer have? They start with PFP.

  • Podocyte foot processes.

In general, what kinds of molecules cannot pass through the glomerular filtration barrier?

  • Larger molecules that have a negative charge.

What syndrome involves a loss of the charge barrier? It starts with NS.

  • Nephrotic syndrome.

Alphabetically, list the four pathologies that may result. I’ll cue you with the first letter of each.

First, A.

  • Albuminuria.

Second, E.

  • Edema.

Third, H.

  • Hyperlipidemia.

Fourth, H again.

  •  Hypoproteinemia.

Student doctor, please pause the tape and summarize what we’ve discussed about the glomerular filtration barrier. The glomerular filtration barrier is composed of three layers.

The fenestrated capillary endothelium is against the blood. This is a size barrier with filtration pores between 7.5 and 10 nanometers in diameter. The fused basement membrane which contains heparin sulfate, is in the middle. This layer is a negative charge barrier that repels albumin in the blood. The layer on the nephron side is the epithelial layer. It comprises podocyte foot processes. In general larger molecules that have a negative charge cannot pass through the glomerular filtration barrier. The Nephrotic syndrome involves a loss of the charge barrier. This can cause albuminuria, edema, hyperlipidemia, and hypoproteinemia.

****END OF TRANSCRIPTION****

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