USMLE Step 1 Renal Physiology 1 Review 58 18 Glucose Reabsorption & Excretion

USMLE Step 1 Renal Physiology 1 Review 58 18 Glucose Reabsorption & Excretion

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Play USMLE Audio MP3 58 18 Glucose Reabsorption & Excretion Below

Begin 58 18 Glucose Reabsorption & Excretion Transcription

Why is glucose usually not excreted in the urine?

  • Normally all the filtered glucose is reabsorbed.

Where is glucose reabsorbed?

  • 99% in the proximal tubule and 1% in the collecting duct.

What is a normal value for plasma glucose concentration? Give your answer in mg/dL.

  • Normal plasma glucose concentration is about 80 to 100 mg/dL.

At a constant glomerular filtration rate what happens to the filtered load of glucoase as plasma glucose increases?

  • The filtered load also increases.

What occurs as the threshold concentration for glucose has been reached?

  • Easily detectable amounts of glucose begin to appear in the urine.

What is the plasma glucose threshold concetration?

  • About 200 mg/dL.

If plasma glucose concentration continues to increase what happens to the kidney’s transport sites for glucose?

  • They become saturated. This means that the transport maximum for glucose has been reached.

What is the transport maximum for glucose? Give your answer in mg/min.

  • 375 mg/min.

What is the approximate plasma glucose concentration when this occurs?

  • When the transport maximum for glucose has been reached, plasma glucose concentration is probably about 350 mg/dL.

Student doctor, please pause the tape and summarize what we’ve discussed about the reabsorption and excretion of glucose.

  • Glucose isn’t usually excreted in the urine because normally, all filtered glucose is reabsorbed. 99% in the proximal tubule and 1% in the collecting ducts. Normal plasma glucose concentration is about 80 to 100 mg/dL. At a constant glomerular filtration rate, the filtered load of glucose increases as plasma glucose increases. When plasma glucose concentration is about 200 mg/dL the threshold concentration for glucose has been reached and easily detectable amounts of glucose begin to be excreted in the urine. If plasma glucose concentration continues to increase the kidney’s transport sites for glucose become saturated. This means that the transport maximum for glucose which is about 375 mg/min, has been reached. When this occurs, plasma glucose concentration is probably about 350 mg/dL.

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