USMLE Step 1 Renal Physiology Review 59 13 Excessive & Insufficient ADH Secretion

USMLE Step 1 Renal Physiology Review 59 13 Excessive & Insufficient ADH Secretion

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Play USMLE Audio MP3  59 13 Excessive & Insufficient ADH Secretion Below

Begin  59 13 Excessive & Insufficient ADH Secretion Transcription

What syndrome is characterized by excessive antidiuretic hormone secretion?

  • SIADH or syndrome of inappropriate secretion of antidiuretic hormone.

What does this syndrome cause? It starts with O.

  • The syndrome of inappropriate secretion of ADH causes overhydration.

What are two things that occur when a person with this syndrome drinks water? They start with E and WR.

  • Edema and water retention.

What is used to treat SIADH? It starts with a D.

  • Demeclocycline is used to treat SIADH.

What disease is characterized by insufficient antidiuretic hormone secretion? It starts with DI.

  • Diabetes insipidus is characterized by insufficient secretion of antidiuretic hormone.

What effect does insufficient ADH secretion have on water reabsorpion in the collecting ducts?

  • Water reabsorption decreases. This leads to the excretion of excessively large volumes of dilute urine.

What is this condition called? It starts with a P.

  • Polyuria.

What are the two types of diabetes insipidus? Both start with the letter N.

  • Neurogenic and nephrogenic.

Which one of these responds to injected vasopressin?

  • Neurogenic diabetes insipidus responds to injected vasopressin.

What can be used to treat both neurogenic and nephrogenic diabetes insipidus? They start with TD.

  • Thiazide diuretics.

Student doctor, please pause the tape and summarize what we’ve discussed about the syndrome of inappropriate secretion of ADH and diabetes insipidus. SIADH or the syndrome of inappropriate secretion of antidiuretic hormone is characterized by excessive ADH secretion.

This syndrome causes overhydration and when a person with the syndrome of inappropriate secretion of ADH drinks water, edema and water retention can result. It is treated with demeclocycline. Diabetes insipidus is characterized by insufficient ADH secretion which causes decreased water reabsorption in the collecting ducts. This leads to polyuria which is the excretion of excessively large volumes of dilute urine. Neurogenic diabetes insipidus responds to injected vasopressin. Thiazide diuretics can be used to treat both neurogenic and nephrogenic diabetes insipidus.

 


 

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