USMLE Step 1 Renal Physiology Review 59 14 ADH Trivia

USMLE Step 1 Renal Physiology Review 59 14 ADH Trivia

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Play USMLE Audio MP3  59 14 ADH Trivia Below

Begin  59 14 ADH Trivia Transcription

Now let’s talk about some ADH trivia. Specifically what kind of polypeptide is ADH?

  • A nonapeptide.

And is this written in stone?

  • No. ADH can also be considered an octapeptide depending on whether you combine the two cysteine residues or not.

What is the molecular weight of ADH?

  • 1100 daltons.

What is its biological half-life?

  • 16 to 20 minutes.

Where is it reabsorbed?

  • In the proximal tubule.

Where does it act?

  • In the late distal tubule and the collecting duct.

What organ metabolizes it?

  • The liver.

What is the specific name for the form of ADH that is biologically active in humans? It starts with AV.

  • Arginine vasopressin.

How big of an increase in plasma osmolality triggers ADH secretion?

  • An increase of only 1 to 2%.

The caffeine in what popular beverage inhibits the secretion of ADH?

  • Coffee.

How is being immersed in water up to your neck going to affect ADH release?

  • ADH release will be inhibited.

What is a potentially deadly habit that stimulates secretion of ADH?

  • Smoking.

Student doctor please pause the tape and summarize the ADH Trivia.

Specifically, ADH is a nonapeptide or an octapeptide depending on whether you combine the two cysteine residues or not. Its molecular weight is 1100 daltons and it has a biological half-life of 16 to 20 minutes. ADH is reabsorbed in the proximal tubule and it acts in the late distal tubule and collecting duct. It is metabolized in the liver. The specific name for the form of ADH that is biologically active in humans is arginine vasopressin. An increase of only 1 to 2% in plasma osmolality triggers ADH secretion. The caffeine in coffee inhibits secretion of ADH as does being immersed in water up to the neck and smoking stimulates secretion.


 

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