USMLE Step 1 Renal Physiology Review 59 15 Kidney Endocrine Products

USMLE Step 1 Renal Physiology Review 59 15 Kidney Endocrine Products

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Play USMLE Audio MP3   59 15 Kidney Endocrine Products  Below

Begin   59 15 Kidney Endocrine Products Transcription

Moving now to kidney endocrine products. What kidney product is a form of Vitamin D?

  • 1,25-dihydroxy-vitamin D.

What hormone triggers the creation of 1,25-dihydroxy-vitamin D?

  • Parathyroid hormone, PTH triggers the creation of 1,25-dihydroxy-vitamin D.

What does the kidney make this vitamin from?

  • 25-hydroxy-vitamin D.

And what is the enzyme?

  • 1-alpha-hydroxylase.

Alphabetically list the three other products produced by the kidneys. I’ll cue you with the first letter of each.

First, E.

Erythropoietin.

Second, P.

Prostaglandins.
Third, R.

Renin.

We’ll discuss renin in the next section.

First, what condition triggers secretion of erythropoietin by the kidney? It starts with H.

  • Hypoxemia triggers the kidney’s secretion of erythropoietin.

Where in the kidney is erythropoietin secreted?

  • In the peritubular capillaries.

What peritubular cells secrete it?

  • The endothelial cells.

What are prostaglandins? The answer starts with V.

  • Prostaglandins are vasodilators.

Vasodilators of what kidney vessels?

  • The afferent arterioles.

Why do the prostaglandins act?

  • To raise the glomerular filtration rate.

What can the prostaglandins be suppressed by? The answer starts with NA.

  • Nonsteroidal anti-inflammatories suppress the prostaglandins.

Student doctor, please pause the tape and summarize what we’ve discussed about kidney endocrine products.

Four kidney products are 1,25-dihydroxy-vitamin D, erythropoietin, prostaglandins, and renin. The kidney makes 1,25-dihydroxy-vitamin D from 25-hydroxy-vitamin D. Parathyroid hormone, PTH, triggers the creation of 1,25-dihydroxy-vitamin D and the enzyme is 1-alpha-hydroxylase. Erythropoietin is secreted by the endothelial cells of the peritubular capillaries. This is triggered by hypoxemia. Prostaglandins are vasodilators of the afferent arterioles. They act to raise the glomerular filtration rate and can be suppressed by nonsteroidal anti-inflammatories.


 

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