USMLE Step 2 Review 18 07 Drugs of Choice Pediatric Lead Poisoning

USMLE Step 2 Review 18 07 Drugs of Choice Pediatric Lead Poisoning

 

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Play USMLE Audio MP3 18 07 Drugs of Choice Pediatric Lead Poisoning Below

 

Begin 18 07 Drugs of Choice Pediatric Lead Poisoning Transcription

What is the drug of choice for pediatric lead poisoning?

  • Succimer.

And the trade name for Succimer?

  • Chemet.

What is an alternative to Succimer/Chemet for lead poisoning, especially for adults?

  • EDTA.

And what is the trade name for EDTA?

  • Calcium Disodium Versenate.

What is the organism in body lice?

  • Pediculosis humanus corporis.

And the topical drug of choice for body lice?

  • Pyrethrins with piperonyl butoxide.

And what’s the trade name for Pyrethrins with piperonyl butoxide?

  • RNC.

What is the drug of choice for prevention of hyperuricemia, which is secondary to cancer therapy only?

  • Allopurinol.

And trade name for Allopurinol?

  • Zyloprim.

What kind of microorganism is nocardiosis?

  • A fungus.

And what is the family of anti-metabolites that are drugs of choice for nocardiosis?

  • The sulfas.

In patients with AIDS, what 3 types of infections are seen in nocardiosis (Give the type of infection, and the location in the body)?

  • Pneumonia in the lungs, abscesses in the brain, sepsis that is systemic.

Again, family of drugs for nocardiosis pneumonia, nocardiosis brain abscesses, and nocardiosis sepsis, especially in AIDS patients?

  • The sulfas.

Because they are very inexpensive, the sulfas are also often used as a first line of defense in another general type of infection. What is it?

  • Urinary tract infections with 1 exception.

And what is the exception?

  • Acute kidney infections.

What is the combination drug of choice including a sulfa for non-acute kidney infections?

  • Give the abbreviation. TMP-SMX.

And what does TMP-SMX stand for?

  • Trimethoprim-Sulfamethoxazole, often referred to as Trimethoprim Sulfa.

Give 2 trade names for Trimethoprim Sulfa?

  • Bactrim, Septra.

TMP-SMX also has a number of applications. Name a general lung pathology in HIV positive patients treatable with TMP-SMX?

  • HIV positive pneumonia.

What are 2 specific conditions that TMP-SMX is used prophylactically for in HIV positive patients?

  • PCP and toxoplasmosis.

What does PCP stand for? Pneumocystis carinii pneumonia. Again- drug of choice for prophylaxis of PCP and toxoplasmosis in HIV positive patients (Give generic and 2 trade names)?

  • Trimethoprim Sulfa/Bactrim/Septra.

Now, what is the combination drug of choice for ongoing infection with toxoplasmosis?

  • Pyrimethamine sulfadiazine

And what’s the trade name for Pyrimethamine sulfadiazine?

  • Fansidar.

What analgesic is the drug of choice for urinary discomfort or irritation, and is often combined with an antibiotic?

  • Phenazopyridine.

And what is the trade name for Phenazopyridine?

  • Pyridium.

What does Phenazopyridine/Pyridium do to urine?

  • It turns it red/orange.

If a patient on Phenazopyridine/Pyridium turns yellow, what would be the cause, if the skin yellowing is from Pyridium?

  • Renal insufficiency.

What is the drug of choice for virtually all of the flukes?

  • The blood flukes known as the schistosomas.

The liver flukes, lung flukes, and intestinal flukes?

  • Praziquantel.

And the trade name for Praziquantel?

  • Biltricide.

Again- generic and trade name for almost all of the flukes?

  • Praziquantel/Biltricide.

Now, what is the drug of choice for flukes in humans that are liver flukes in sheep?

  • Bithionol.

What are the 2 drugs of choice for treating depression when it is accompanied by agitated states?

  • Either Amitriptyline with Perphenazine or Doxepin.

And what’s the trade name for Amitriptyline with Perphenazine?

  • Etrafon.

And the trade name for Doxepin in PO form?

  • Sinequan.

What class of drug is Amitriptyline and Doxepin both?

  • Tricyclic antidepressants.

What class of drug is Perphenazine, which is together with the Amitriptyline?

  • A pyridine pyrathiazine antipsychotic.

What is the drug of choice for mercury poisoning?

  • Dimercaprol.

And the trade name for Dimercaprol?

  • BAL in oil.

****END OF TRANSCRIPTION****

 

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